Native Canine Probiotic

Canine-native probiotic strains, scientifically studied*and designed to support digestive balance through a clear, clinically relevant system.​

From dogs, for dogs.

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ELEVATING MICROBIOME CARE IN VETERINARY PRACTICE​

The Gut Microbiome as a Foundation​ of Canine Health​
Research continues to show the gut microbiome plays a critical role in digestion, immune function, and overall resilience — making microbiome support a key component of comprehensive care.​

A Common and Clinically Relevant Challenge
​Digestive disruption, including episodes of occasional diarrhea, remains one of the most frequent reasons dogs present to veterinary clinics.​

A Break-through, Innovative Solution for Veterinary Practice​

Zesty Paws® Professional Native Canine Probiotic was developed with exclusive canine-native probiotic strains and a clear, time-bound veterinary protocol to support digestive balance during periods of microbiome disruption, with a defined pathway for ongoing maintenance. ​

A COMPLETE APPROACH TO CANINE GUT HEALTH

Supporting clinical care every step of the way — from GI disruption to long-term gut health support.

7-Day Protocol

Higher Inclusion for Timely Gut Support

18 Million CFUs per packet

Supports digestive balance during periods of disruption through a short-term, clearly defined approach.

Daily Maintenance​

Flexible Dosage for Daily Gut Support

6 Million CFUs per packet

Supports ongoing gut health and microbiome stability.

Use Cases

Clinical Use Cases Appropriate for dogs experiencing:

  • Occasional diarrhea
  • Digestive disruption related to stress, diet changes, or environmental factors
  • Sensitive stomach patterns

Can be used alongside:

  • Bland Diet
  • Hydration strategies
  • Other veterinarian-recommended digestive support strategies

Breakthrough Science: Canine-Native Strains

Powered by Canine Triple Shield™

Native Canine Probiotic was developed in partnership with Native Microbials, using its advanced genomics platform to study the healthy canine gut microbiome.

From extensive analysis of stool samples from healthy dogs, microbial strains were evaluated for prevalence, biological relevance, and association with digestive balance.

From over 100 candidates, three canine-native strains were selected for their complementary roles in supporting microbiome stability, specially during periods of disruption.

The Canine Triple Shield™ System

Enterococcus faecium

A canine-native probiotic strain commonly found in the healthy gut, associated with stool consistency and balanced gut microbiota.

Three Canine-Native Probiotic Strains Aligned with a Dog's Natural Biology

Enterococcus faecium, Megamonas funiformis, Peptacetibacter hiranonis

Together, these three strains form Canine Triple Shield™ — a synergistic system selected for canine relevance, microbiome interaction, and complementary mechanisms, rather than generic strain availability.

Scientifically Studied Formula*

The formulation used in Zesty Paws® Professional Native Canine Probiotic has been evaluated through pre-clinical research and observational case studies designed to better understand its interaction with the canine gut microbiome.​

These studies focused on small sample privately owned dogs experiencing digestive disruption, including loose stools, and evaluated changes in stool quality, microbiome composition, and owner-reported observations over time. Microbiome analysis was conducted using fecal sampling at defined intervals to assess shifts in bacterial populations associated with digestive balance.​

​A Complete Clinical Trial is on its way​

​A Full Clinical Trial evaluating Native Canine Probiotic™ is currently underway and is expected to be made publicly available in the first half of 2026. This study is designed to further assess digestive outcomes and microbiome changes over an extended period. ​

Pre-Clinical & Observational Findings*

  • The majority of dogs showed healthier microbiome population by Day 7*​
  • The majority of dogs displayed an improved microbiome balance*​
  • 72% of dogs showed improved fecal quality within 7 days*​
  • Continued daily administration supported a more balanced and diverse gut microbiome over time.​

Case Study Insights​
The owners of dogs involved in the Patient Controlled study reported:

  • Enhanced overall well-being​
  • Improved stool quality​
  • Increased appetite & activity​
  • Increased GI function​
*Based on early clinical data from a small-sample study conducted in 2023.
Full clinical trial expected to be released H1 2026.
**Based off Patient Controlled Prospective Study, 2024.

Why Work with Zesty Paws® Professional™?​

A Trusted Partner in Pet Health​

Since 2015, Zesty Paws® has been dedicated to elevating pet health through science-led nutrition and purposeful innovation. What began as a commitment to better functional supplements for pets has grown into one of the most trusted pet wellness brands among pet parents in the U.S. and beyond.​

Today, Zesty Paws® is trusted by millions of pet parents and offers a broad portfolio of products designed to support functional health needs across every life stage — from digestive health and mobility to immune support and healthy aging.​

With Zesty Paws Professional™, we bring that same science-first approach into the veterinary channel — developing products with biological relevance, clinical practicality, and long-term partnership in mind. Our goal is not to replace veterinary expertise, but to support it with solutions that are easy to recommend, easy to use, and aligned with modern standards of care.

*Ratings and reviews based on all Zesty Paws® supplements on all eCommerce channels in the US and ZestyPaws.com as of August 2025.

Why Professionals Choose to Partner with Zesty Paws®​

Proven Brand
Trust​

A recognized and trusted brand among hundreds of thousands* of pet parents — helping reinforce confidence at the point of recommendation.

Science-Led Product Development

Products are developed with scientific and veterinary input, supported by research, observational insights, and ongoing evaluation.

Clinically Relevant
Solutions

Clear protocols and product systems designed to integrate seamlessly into veterinary workflows.

Long-Term Category Commitment​

A growing Professional™ portfolio focused on digestive health, healthy aging, and future science-driven innovations.

Partnership
Mindset

Dedicated to education, transparency, and collaboration with veterinary professionals and distributors.

*Based on over 380,000 5-Star Ratings and Reviews on all Zesty Paws® supplements on all eCommerce channels in the US and ZestyPaws.com as of August 2025.

Connect with Us About Zesty Paws Professional™​

Learn more about our products, educational resources, and partnership opportunities.​

For veterinary professionals and industry partners.

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