A New Breed Of Probiotics

Three canine-native strains for occasional diarrhea.

For Veterinary Professionals Ahead of the Curve

Request a Sample Today!

Start with a complimentary sample of our innovative probiotics to see how these strains work synergistically with the canine gut microbiome. 

Our Professional Portfolio

Products developed for veterinary use — grounded in research, built for clinical relevance, and designed to support modern practice needs. For veterinarians, practice managers, and professional partners.

Native Canine Probiotic

Next Generation of Canine Probiotics


Zesty Paws® Professional Native Canine Probiotic was developed with exclusive canine-native probiotic strains and a clear, time-bound veterinary protocol to support digestive balance during periods of microbiome disruption, with a defined pathway for ongoing maintenance.

Healthy Aging

The Evolution of Canine Cellular Health


As dogs age, their natural DNA repair mechanisms gradually decline. Our Zesty Paws® Professional NAD+ precursor supports revitalizing these cellular processes —to promote optimal cellular function and overall vitality so dogs can stay energetic and healthy longer.

PRE-clinical & clinical evidence

Science Behind the Product

Canine Triple Shield™ is supported by a progressive body of evidence — from third party lab testing, to real-world veterinary case studies to early clinical pilot study already published — each examining how the three canine-native strains behave in dogs experiencing digestive disruption.

Early Clinical Findings in Dogs*

In a pilot study of dogs presenting with chronic diarrhea (>5 days)*, the formulation was well tolerated with no reported adverse events. The majority of dogs showed:

  • The majority of dogs showed healthier microbiome population by Day 7*​
  • The majority of dogs displayed an improved microbiome balance*​
  • 72% of dogs showed improved fecal quality within 7 days*​
  • Continued daily administration supported a more balanced and diverse gut microbiome over time.​

Case Study Insights​**

The owners of dogs involved in the Patient Controlled study reported:

  • Enhanced overall well-being​
  • Improved stool quality​
  • Increased appetite & activity​
  • Increased GI function​

Ongoing Research

Native Canine Probiotic's strain science continues to be studied through additional pre-clinical, clinical and field research to further characterize digestive and microbiome outcomes. Stay tuned for more information.

*Doshier J, Anderson B, Yang F, Stewart SD, Calapa KA, Cooper R, Wilson-Robles H, Embree M and Khanna C (2026) Pilot study evaluating tolerability and changes in fecal microbiota associated with novel probiotic administration to dogs with diarrhea. Front. Vet. Sci. 12:1720932. doi: 10.3389/fvets.2025.1720932
**Based off Patient Controlled Prospective Study, 2024.

A Trusted Partner in Pet Health​

Why Work with Zesty Paws® Professional™?​

Since 2015, Zesty Paws® has been dedicated to elevating pet health through science-led nutrition and purposeful innovation. What began as a commitment to better functional supplements for pets has grown into one of the most trusted pet wellness brands among pet parents in the U.S. and beyond.​

Today, Zesty Paws® is trusted by hundreds of thousands of pet parents and offers a broad portfolio of products designed to support functional health needs across every life stage — from digestive health and mobility to immune support and healthy aging.​

With Zesty Paws Professional™, we bring that same science-first approach into the veterinary channel — developing products with biological relevance, clinical practicality, and long-term partnership in mind. Our goal is not to replace veterinary expertise, but to support it with solutions that are easy to recommend, easy to use, and aligned with modern standards of care.

*Ratings and reviews based on all Zesty Paws® supplements on all eCommerce channels in the US and ZestyPaws.com as of August 2025.

Why Professionals Choose to Partner with Zesty Paws®​

Proven Brand Trust

A recognized and trusted brand among hundreds of thousands* of pet parents — helping reinforce confidence at the point of recommendation.

Science-Led Product Development

Products are developed with scientific and veterinary input, supported by research, observational insights, and ongoing evaluation.

Clinically Relevant Solutions

Clear protocols and product systems designed to integrate seamlessly into veterinary workflows.

Long-Term Category Commitment​

A growing Professional™ portfolio focused on digestive health, healthy aging, and future science-driven innovations.

Partnership Mindset

Dedicated to education, transparency, and collaboration with veterinary professionals and distributors.

For veterinary professionals and industry partners.

Connect with Us About Zesty Paws Professional™​

Learn more about our products, educational resources, and partnership opportunities.​

For Veterinary Professionals Ahead of the Curve

Request a Sample Today!